1r26

Publication Abstract from PubMed
The three-dimensional structure of thioredoxin from Trypanosoma brucei brucei has been determined at 1.4 A resolution. The overall structure is more similar to that of human thioredoxin than to any other thioredoxin structure. The most striking difference to other thioredoxins is the absence of a buried carboxylate behind the active site cysteines. Instead of the common Asp, there is a Trp that binds an ordered water molecule probably involved in the protonation/deprotonation of the more buried cysteine during catalysis. The conserved Trp in the WCGPC sequence motif has an exposed position that can interact with target proteins.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

About this Structure
1R26 is a 1 chain structure of sequence from Trypanosoma brucei brucei. Full crystallographic information is available from OCA.

Reference
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